Romelu Lukaku is on the bench for Napoli and is ready to make his debut, but Khvicha Kvaratskhelia and Giacomo Raspadori will start against league leaders Parma.
Kick-off is at the Stadio Diego Armando Maradona at 7:45pm British time (6:45pm GMT).
On the LIVEBLOG you can follow all the preparation and action of today's four Serie A games live.
Antonio Conte has had a mixed start in Napoli, needing a penalty shootout to narrowly beat Modena in the Coppa Italia and losing 3-0 at Verona in Serie A, but last week he beat Bologna 3-0.
They have also finally signed the players he asked for, namely Lukaku, Billy Gilmour and Scott McTominay, although today only the Belgian is on the bench.
Of course, there was also the drama surrounding Victor Osimhen, who was excluded from the squad for the foreseeable future and Lukaku was given his shirt number.
David Neres is also on the bench after providing an assist on his brief debut.
Fabio Pecchia's Parma made a big impression after their promotion by keeping Fiorentina at bay and beating Milan 2-1.
Hernani, Yordan Osorio and Adrian Benedyczak remain out of action, but Ange-Yoan Bonny moves into a deeper role with Romanian internationals Dennis Man and Valentin Mihaila, while 19-year-old Mateusz Kowalski starts in attack.
Naples vs Parma – where to watch on TV
In the USA, the game will be broadcast on Paramount+. Fans in the UK and Ireland can watch it for free on OneFootball. beIN SPORTS 1 and the streaming service beIN SPORTS CONNECT will broadcast the duel at the Stadio Maradona live in Australia and New Zealand.
Lineups Napoli vs. Parma
Naples: Meret; Di Lorenzo, Rrahmani, Buongiorno; Mazzocchi, Anguissa, Lobotka, Olivera; Politano, Kvaratskhelia; Raspadori
Parma: Suzuki; Coulibaly, Balogh, Circati, Valeri; Bernabè, Sohm; Man, Bonny, Mihaila; Kowalski
